Revenues ( 2016 ) - $ 40.18 billion Home country : USA

Whether you measure it by fleet size , revenue , passenger-kilometres flown , or number of destinations it serves , American Airlines is the world ’ s largest airline . Winning Cargo Airline of the Year 2017 , its cargo division provides over 100 million pounds of weekly cargo lift worldwide and employs nearly 5,000 people .

Revenues ( 2016 ) - $ 19.9 billion Home country : USA

Dominating the cross-country rail freight market in the USA , Union Pacific deploys over 8,500 locomotives across 32,100 routemiles which span 23 US states . Tracing its origins back to the Pacific Railroad Act of 1842 , the company has played a unique role in shaping the development of the world ’ s largest economy .

Revenues ( 2016 ) - $ 39.64 billion Home country : USA Another massive American air carrier , Delta Airlines is the second largest in the country measured across many variables . Delta Cargo offers a range of specialist transportation solutions , including perishables , pharmaceuticals , express , and high value items . Delta also offers a premium DASH service for high priority deliveries that reserves priority places aboard its aircraft .

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